How Spravato Works
Finding the right mental health treatment can feel like a difficult fight. You may navigate challenges, such as unwanted side effects, long adjustment periods while awaiting results, or steep costs that insurance does not cover. Often, traditional medications require experimentation, and finding one that works is not guaranteed.
If you are struggling with depression and still searching for relief, Spravato may be right for you. This innovative nasal spray is effective for those who have not had success with other methods, such as antidepressant medication. Our dedicated team is here to help you understand how Spravato works and whether this advanced treatment may be right for you.
What Is Spravato?
Spravato is an innovative method to manage treatment-resistant depression (TRD) and major depressive disorder that is FDA-approved and considered safe and highly effective for most people. It is delivered as a nasal spray formulated with esketamine, a compound that boosts mood and heals parts of the brain affected by chronic depression. Spravato continues to gain notice for how it creates symptom relief more quickly and effectively than traditional antidepressants.
This is a patient-administered medication, but you will not go through the process alone. After taking Spravato, you will remain in our office for at least two hours, where you will be closely monitored by Spravato-certified treaters and an APRN to ensure your safety and comfort.
How Does Spravato Work?
Esketamine, the main compound in Spravato, works differently than traditional SSRI or SNRI antidepressants, making it a worthwhile treatment option for those with TRD. Spravato targets the brain’s glutamate receptors, which regulate mood and cognitive function. It also boosts neuroplasticity—the brain’s ability to adapt and form new connections—potentially healing damage caused by chronic depression.
While oral medications are effective for some, one in three people experience little to no improvement. Often, people must navigate unpleasant side effects that make antidepressants intolerable. Current research shows that 88 percent of patients experienced a significant reduction in symptoms after one Spravato treatment.
What To Expect During Treatments
Spravato is delivered in phases. During the first four weeks (induction), you will come to our office twice per week. In weeks five through eight, dosing typically occurs once per week to stabilize your response. After week eight, we transition to the maintenance phase—generally every other week and adjusted as needed based on your progress.
Studies show that patients who continued to use Spravato at least every other week after completing their induction and maintenance phases were less likely to experience a relapse in depression symptoms compared to those who stopped treatments.
While many patients experience an improved mood after the first 24 hours of Spravato use, you should feel significant symptom reduction after the first four weeks of treatment. You must closely monitor your mental and physical wellness during this time. Let us know of any changes, so we can make the necessary adjustments for optimal results.
Contact Us To Learn How Spravato Might Affect Your Depression
If traditional treatments for depression have not worked for you, Spravato may be your long-awaited solution. At Arkansas Psychiatric Clinic, our compassionate team has helped many patients rediscover mental wellness through facilitated Spravato care. Contact us today to learn more about how Spravato works and begin your journey toward improved well-being.